Pricing & Details

Product No.I-466
Protein
Lipe
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Hormone-Sensitive Lipase, HSL
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-466-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
I-466-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:I-487
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Lipe recognizes Human, Mouse and Rat Lipe. This polyclonal antibody was purified using affinity chromatography.
Background
Although initially described as an adipocyte-specific triacylglycerol lipase, lipe (also known as hormone-specific lipase or HSL) is expressed in multiple tissues and cell lines. It plays multiple roles in lipid metabolism, including hormone-stimulated lipolysis in adipose tissue and the hydrolysis of cholesterol esters. Lipe is expressed as a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesterol esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. Recently, it was observed that the lack of lipe in genetically obese leptin-null mice inhibited obesity and adipogenesis, suggesting that lipe plays a major role in adipocyte proliferation.

Antigen Details

Protein
PubMed

References & Citations

1. Yeaman, SJ. (2004) Biochem. J. 379:11
2. Holst, LS. et al. (1996) Genomics 35:441
3. Kraemer, FB. et al. (2004) Mol. Endocrinol. 18:549
4. Sekiya, M. et al. (2004) J. Biol. Chem. 279:15084
General Western Blot Protocol
Prod No.
Description
I-487
I-466
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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