Anti-Human LSD1 (NT)

Pricing & Details

Product No.L174
Protein
LSD1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Lysine-Specific Histone Demethylase, Amine Oxidase Flavin Containing Domain Protein 2, AOF2
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
L174-20 ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
L174-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:L176
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human LSD1 recognizes on epitope near the amino terminus of human, mouse and rat LSD1. This polyclonal antibody was purified using affinity chromatography.
Background
Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1). Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2). LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation (3,4). Experiments have shown that CoREST, a SANT domain-containing corepressor (5) acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein (6), inhibits CoREST/LSD1 activity in vitro (3). LSD1-mediated histone demethylation thus may have significant effects on gene expression.

Antigen Details

Protein
PubMed

References & Citations

1. Shi, Y. et al. (2004) Cell 119:941
2. Kouzarides, T. (2002) Curr. Opin. Genet. Dev. 12:198
3. Shi, Y. et al. (2005) Mol. Cell 19:857
4. Nakamura, T. et al. (2002) Mol. Cell 10:1119
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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