Anti-Human Modulator of Apoptosis 1 (Intermediate Domain) (MAP1)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Modulator of Apoptosis 1 (Intermediate Domain) (MAP1)

Pricing & Details

Product No.M1210
Protein
MAP-1
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
M1210-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
M1210-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:M1214
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Modulator of Apoptosis 1 (MAP1) recognizes an epitope in the intermediate domain of Human and Mouse MAP1. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo.4 It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

Antigen Details

Protein
PubMed

References & Citations

1. Lockshin, RA. et al. (2000) Cell Death Differ. 7:2
2. Cory, S. et al. (2003) Oncogene 22:8590
3. Heiser, D. et al. (2004) Exp. Geron. 39:1125
4. Tan, KO. et al. (2001) J. Biol. Chem. 276:2802
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Leinco Technologies uses cookies to improve your experience and our website service. By continuing to browse our website, you accept our cookie policy. Ok