Pricing & Details

Product No.N155
Protein
NADE
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
N155-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
N155-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:N168
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human NADE recognizes Human and Mouse NADE. This polyclonal antibody was purified using affinity chromatography.
Background
The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR.2 Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells,3 NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.4

Antigen Details

Protein
PubMed

References & Citations

1. Gentry, JJ. et al. (2004) Pro. Brain Res. 146:25
2. Mukai, J. et al. (2000) J. Biol. Chem. 275:17566
3. Rapp, G. et al. (1990) DNA Cell Biol. 9:479
4. Yi, JS. et al. (2003) Neurosci. Lett. 347:126
IHC
General Western Blot Protocol
Prod No.
Description
N168
N155
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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