Pricing & Details

Product No.N161
Protein
Noxa
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
PMA-Induced Protein 1, PMAIP1, APR
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
N161-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
N161-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:N174
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Noxa recognizes Human, Mouse and Rat Noxa. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53.1-3 Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.4

Antigen Details

Protein
PubMed

References & Citations

1. Oda, E. et al. (2000) Science 288:1053
2. Nakano, K. et al. (2001) Mol. Cell 7:683
3. Yu, J. et al. (2001) Mol. Cell 7:673
4. Eferl, R. et al. (2003) Cell 112:181
IHC
General Western Blot Protocol
Prod No.
Description
N174
N161
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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