Anti-Human OMI (CT-2)

Pricing & Details

Product No.O113
Protein
OMI
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
HtrA2
Applications
IHC FF
,
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
O113-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
O113-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:O116
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human OMI recognizes an eptiope near the C-terminus of Human OMI. This polyclonal antibody was purified using affinity chromatography.
Background
Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication.1 Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases (reviewed in 2). The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs (reviewed in 3). Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs.4 Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.

Antigen Details

Protein
PubMed

References & Citations

1. Crook, NE. et al. (1993) J. Virol. 67:2168
2. Liston, P. et al. (2003) Oncogene 22:8568
3. Vaux, DL. et al. (2003) Biochem. Biophys. Res. Comm. 304:499
4. Suzuki, Y. et al. (2001) Mol. Cell 8:613
IHC
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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