Anti-Human P21-Activated Kinase 2 (NT) (PAK2)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human P21-Activated Kinase 2 (NT) (PAK2)

Pricing & Details

Product No.P192
Protein
P21-Activated Kinase 2
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
PAK65
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
P192-20 µg
20 µg
$95.00
In stock
Max:
Min: 1
Step: 1
P192-0.1 mg
0.1 mg
$440.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:P199
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human P21-Activated Kinase 2 (PAK2) recognizes an epitope near the N-terminus of Human, Mouse and Rat PAK2. This polyclonal antibody was purified using affinity chromatography.
Background
The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.

Antigen Details

References & Citations

1. Jaffer, ZM. et al. (2004) Cell Biol. 34:713
2. Rudel, T. et al. (1997) Science 276:1571
3. Vilas, GL. et al. (2006) Proc. Natl. Acad. Sci. USA 103:6542
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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