Pricing & Details

Product No.P225
Protein
PARC
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
p53-associated Parkin-like Cytoplasmic Protein, UbcH7-associated Protein 1
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
P225-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
P225-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human PARC recognizes an epitope near the carboxy terminus of human and mouse PARC. This polyclonal antibody was purified using affinity chromatography.
Background
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.

Antigen Details

Protein
PubMed

References & Citations

1. Puskas, N. et al. (2003) Cell 112:29-40.
2. DeCaprio, JA. et al. (2005) Mol. Cell. Biol. 25:5579-89.
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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