Anti-Human Placental Lactogen – Purified

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Pricing & Details

Product No.L103
Clone
178
Protein
Placental Lactogen
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
Mouse
IgG
Prod No.
Size
Price
Avail.
Qty
Add to cart
L103-1.0 mg
1.0 mg
$178.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human Placental Lactogen (>98%)
Product Concentration
1.0 mg/ml
Formulation
This purified antibody is supplied in 0.01 M phosphate buffered saline (PBS), pH 7.4, containing 0.09% sodium azide.
Storage and Handling
For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. For short term storage, this monoclonal antibody can be stored at 2 to 8⁰C for at least 4 weeks.
Cross Reactivity
Human prolactin < 0.01%. Human growth hormone < 0.01%.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human Placental Lactogen (Clone 178) recognizes Human Placental Lactogen. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Human placental lactogen (HPL), also called human chorionic somatomammotropin, is a polypeptide placental hormone. Its structure and function is similar to that of human growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus. HPL consists of 190 amino acids that are linked by two disulfite bonds and is secreted by the syncytiotrophoblast during pregnancy. Its molecular weight is 22,125. Like human growth hormone HPL is encoded by genes on chromosome 17q22-24. Its biologic half-life is 15 minutes. HPL affects the metabolic system of the maternal organism. HPL increases production of insulin and IGF-1 and increases insulin resistance and carbohydrate intolerance. Chronic hypoglycemia leads to a rise in HPL. HPL induces lipolysis with the release of free fatty acids, increase in insulin secretion and insulin resistance. With fasting and release of HPL, free fatty acids become available for the maternal organism as fuel, so that relatively more glucose can be utilized by the fetus. Also, ketones formed from free fatty acids can cross the placenta and be used by the fetus. These events support energy supply to the fetus in states of starvation.

Antigen Details

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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