Anti-Human SIRPα (CT)

Pricing & Details

Product No.S487
Protein
SIRP alpha
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
SHPS-1, MyD-1, BIT, p84
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
S487-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
S487-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:S529
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human SIRPα recognizes an epitope near the C-terminus of Human, Mouse and Rat SIRPα. This polyclonal antibody was purified using affinity chromatography.
Background
Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPα, SHPS-1, MyD-1, BIT and p84. SIRPα is a new gene family containing at least fifteen members. SIRPα is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPα has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.

Antigen Details

Protein

References & Citations

1. Kharitonenkov, A. et al. (1997) Nature 386:181
2. Fujioka, Y. et al. (1996) Mol. Cell Biol. 16:6887
3. Yamao, T. et al. (1997) Biochem. Biophys. Res. Commun. 231:61
4. Brooke, GP. et al. (1998) Eur. J. Immunol. 28:1
IHC
General Western Blot Protocol
Prod No.
Description
S487
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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