Anti-Human TGF-β Activated Protein Kinase 1 (TAK1)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human TGF-β Activated Protein Kinase 1 (TAK1)

Pricing & Details

Product No.T276
Protein
TAK1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
MAP3K7
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
T276-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
T276-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:T303
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TGF-β Activated Protein Kinase 1 (TAK1) recognizes Human, Mouse and Rat TAK1. This polyclonal antibody was purified using affinity chromatography.
Background
TAK1 (TGF-β; activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7).1 It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-Β and members of the Toll-IL-1R (TIR) superfamily,2 thus acting as an intermediate in both proliferative and innate and adaptive immune responses.3 TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3.4 Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation, while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity.

Antigen Details

Protein
PubMed

References & Citations

1. Yamaguchi, K. et al. (1995) Science 270:2008
2. Irie, T. et al. (2000) FEBS Lett. 467:160
3. Akira, S. et al. (2004) Nat. Rev. Immunol. 4:499
4. Jiang, Z. et al. (2002) Mol. Cell Biol. 22:7158
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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