Anti-Human TIRAP (Intermediate Domain)
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:T364 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831911 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human TIRAP recognizes an epitope in the intermediate domain of Human TIRAP. This polyclonal antibody was purified using affinity chromatography. Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors (4,5). In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling (6). Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-κB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling (6,7). PubMed References & Citations1. Fenton, MJ. et al. (2003) Mol. Interv. 3:466-77. 2. Akira, S. et al. (2003) Annu.Rev. Immunol. 21:335-76. 3. Janeway Jr., CA. and Medzhitov, R. (2002) Annu. Rev. Immunol. 20:197-216. 4. Bowie, AG. et al. (2003) Trends in Imm. 24:286-9. 5. McGettrick, AF. and O’Neill, LAJ. (2004) MolImm. 41:577-82. 6. Hemmi, H. et al. (2002) Nature 420:324-9. 7. Flavell, RA. et al. (2002) Nature 420:329-333. Technical ProtocolsCertificate of Analysis |
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