Pricing & Details

Product No.T308
Protein
Toso
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Regulator of Fas-Induced Apoptosis, Fas Apoptotic Inhibitory Molecule 3, FAIM3
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
T308-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
T308-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:T324
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Toso recognizes Human Toso. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS-PAGE.

Antigen Details

Protein
PubMed

References & Citations

1. Curtin, JF. et al. (2003) Cell Signal. 15:983
2. Hitoshi, Y. et al. (1998) Immunity 8:461
3. Song, Y. et al. (2005) J. Biol. Chem. 280:9618
General Western Blot Protocol
Prod No.
Description
T324
T308
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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