Anti-Human Transient Receptor Potential Channel 3 (NT) (TRPC3)
Pricing & Details
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human Transient Receptor Potential Channel 3 (TRPC3) recognizes an epitope near the N-terminus of Human and Mouse TRPC3. This polyclonal antibody was purified using affinity chromatography.
The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors (2). TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.
References & Citations
1. Contell, C. et al. (2002) Mol. Cell 9:229
2. Dietrich, A. et al. (2005) Pflugers Arch. 451:72
3. Trebak, M. et al. (2003) Cell Calcium 33:451
Products are for research use only. Not for use in diagnostic or therapeutic procedures.