Anti-Human IDH1 Antibody (34074)
Anti-Human IDH1 Antibody (34074)
Product No.: 34074
- -
- -
Clone G132.1 Target IDH1 Formats AvailableView All Product Type Monoclonal Alternate Names Cytosolic NADP-isocitrate dehydrogenase, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase Isotype Mouse IgG1 Applications IHC |
Data
Immunohistochemistry: Detection of IDH1 R132H in human astrocytoma with #34074 diluted 1:100-1:200. - -
- -
Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Synthetic peptide corresponding to the region of human IDH1 that includes a point mutation at residue 132 where Arginine (R) is changed to Histidine (H) Formulation Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide. State of Matter Liquid Product Preparation Purified by immunoaffinity chromatography Storage and Handling Store at 2-8°C. Do not freeze. Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Monoclonal Antibody specific to IDH1 Background Isocitrate dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic
cycle. Mutations in this enzyme have frequently been identified in astrocytomas, oligodendrogliomas, and oligoastrocytomas as well as in secondary glioblastomas. IDH1 mutations
are found much less frequently in primary glioblastomas. The IDH1 mutations are highly specific
to a single codon in the conserved and functionally important Arg132 in IDH1. NCBI Gene Bank ID UniProt.org Research Area Cancer Research References & Citations |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
