Name: Anti-Human IDH1 Antibody (34074)
SKU: 34074
Price: 245.00 USD
Availability: InStock

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Anti-Human IDH1 Antibody (34074)

Product No.: 34074


Clone G132.1 Target IDH1 Formats AvailableView All Product Type Monoclonal Alternate Names Cytosolic NADP-isocitrate dehydrogenase, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase Isotype Mouse IgG1 Applications IHC


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Data

Immunohistochemistry: Detection of IDH1 R132H in human astrocytoma with #34074 diluted 1:100-1:200.

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Immunogen

Synthetic peptide corresponding to the region of human IDH1 that includes a point mutation at residue 132 where Arginine (R) is changed to Histidine (H)

Formulation

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

State of Matter

Liquid

Product Preparation

Purified by immunoaffinity chromatography

Storage and Handling

Store at 2-8°C. Do not freeze.

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Mouse Monoclonal Antibody specific to IDH1

Background

Isocitrate dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. Mutations in this enzyme have frequently been identified in astrocytomas, oligodendrogliomas, and oligoastrocytomas as well as in secondary glioblastomas. IDH1 mutations are found much less frequently in primary glioblastomas. The IDH1 mutations are highly specific to a single codon in the conserved and functionally important Arg132 in IDH1.

NCBI Gene Bank ID

IDH1

UniProt.org

O75874

Research Area

Cancer Research