Anti-Ku80 Antibody (12525)
Anti-Ku80 Antibody (12525)
Product No.: 12525
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Target Ku80 Product Type Polyclonal Alternate Names EC 3.6.4.-, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, DNA repair protein XRCC5, Ku80, Ku86, Lupus Ku autoantigen protein p86, Nuclear factor IV, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 5 Applications WB |
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Antibody DetailsProduct DetailsReactive Species Hamster ⋅ Human ⋅ Mouse ⋅ Rat Host Species Rabbit Immunogen Synthetic peptide corresponding to amino acids 323-338 (FSKVDEEQMKYKSEGK) of Ku80 conjugated to KLH at the C-terminus. Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use at 1:500 dilution. A band of approximately 80 kDa is detected.
Positive control: A431 and AR42J whole cell lysates. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Polyclonal Antibody specific to Ku80 Background Telomere length maintenance, essential to chromosome stability and genome integrity, is regulated by telomerase and telomere-associated factors. The Ku proteins are eukaryotic nuclear proteins involved in DNA repair and telomere maintenance. They exist as a heterodimer of 70 and 80 kDa subunits (Ku 70 and Ku 80). Ku heterodimers bind to DNA ends at telomeres and at double-strand breaks where they interact with DNA-dependent protein kinase (DNA PK) and participate in targeting of DNA PK to DNA. The Ku proteins may participate in DNA repair and replication, cell signaling, proliferation, transcriptional activation, and apoptosis. Function Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). Required for double-strand break repair and V(D)J rPubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:28712728, PubMed:32103174, PubMed:7957065, PubMed:8621488}. NCBI Gene Bank ID UniProt.org Research Area DNA References & CitationsPark SJ et al. (2004) J Biol Chem 279:6046-55. Technical Protocols Certificate of Analysis |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
