Anti-Mouse CD155 – DyLight® 488
Anti-Mouse CD155 – DyLight® 488
Product No.: C2853
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Clone 4.24.1 Target CD155 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names PVR (poliovirus receptor) homolog, Clone 4.24 Isotype IgG2a κ Applications FC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen EL4 transfected with mouse CD155 Product Concentration 0.2 mg/ml Formulation This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Excitation Laser Blue Laser (493 nm) RRIDAB_2829609 Applications and Recommended Usage? Quality Tested by Leinco FC This antibody can be used at a concentration of ≤ 0.25 µg per 106 cells in a 100 µl total staining volume Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone 4.24.1 recognizes an epitope on mouse CD155. Antigen Distribution CD155 is expressed at cell junctions on the primary vascular endothelial cells and is highly expressed on DP thymocytes. Background CD155 is a transmembrane glycoprotein member of a subfamily of immunoglobulin-like adhesion receptors (nectins). CD155 is commonly known as Poliovirus Receptor (PVR) because of its involvement as a cellular receptor for poliovirus. The normal function of CD155 is to establish intercellular adherens junctions between epithelial cells. Of its 3 extracellular immunoglobulin-like domains (D1, D2, and D3), the virus only recognizes D1. CD155 interacts with both CD226 and CD96 to induce cytotoxicity of NK cells and CTL. The precise role of CD155 in the immune system remains to be elucidated, though it is suspected to be involved in intestinal humoral immune responses. Furthermore, it is thought that CD155 may be used to positively select MHC-independent T cells in the thymus. Antigen DetailsLigand/Receptor CD226 (DNAM-1), CD96 NCBI Gene Bank ID UniProt.org Research Area Immunology . Innate Immunity Technical Protocols |
Formats Available
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
