Anti-Mouse CD155 – DyLight® 488

Anti-Mouse CD155 – DyLight® 488

Product No.: C2853

[product_table name="All Top" skus="C2853"]

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Clone
4.24.1
Target
CD155
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
PVR (poliovirus receptor) homolog, Clone 4.24
Isotype
IgG2a κ
Applications
FC

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rat
Immunogen
EL4 transfected with mouse CD155
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Excitation Laser
Blue Laser (493 nm)
Applications and Recommended Usage?
Quality Tested by Leinco
FC This antibody can be used at a concentration of ≤ 0.25 µg per 106 cells in a 100 µl total staining volume
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 4.24.1 recognizes an epitope on mouse CD155.
Antigen Distribution
CD155 is expressed at cell junctions on the primary vascular endothelial cells and is highly expressed on DP thymocytes.
Background
CD155 is a transmembrane glycoprotein member of a subfamily of immunoglobulin-like adhesion receptors (nectins). CD155 is commonly known as Poliovirus Receptor (PVR) because of its involvement as a cellular receptor for poliovirus. The normal function of CD155 is to establish intercellular adherens junctions between epithelial cells. Of its 3 extracellular immunoglobulin-like domains (D1, D2, and D3), the virus only recognizes D1. CD155 interacts with both CD226 and CD96 to induce cytotoxicity of NK cells and CTL. The precise role of CD155 in the immune system remains to be elucidated, though it is suspected to be involved in intestinal humoral immune responses. Furthermore, it is thought that CD155 may be used to positively select MHC-independent T cells in the thymus.

Antigen Details

Ligand/Receptor
CD226 (DNAM-1), CD96
NCBI Gene Bank ID
Research Area
Immunology
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Innate Immunity
Flow Cytometry

Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.