Anti-Mouse IL-1 Receptor Associated Kinase 2 (CT-2) (IRAK2)

Anti-Mouse IL-1 Receptor Associated Kinase 2 (CT-2) (IRAK2)

Product No.: I-467

[product_table name="All Top" skus="I-467"]

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Target
IRAK2
Product Type
Polyclonal Antibody
Alternate Names
Interleukin-1 Receptor Associated Kinase 2, mIRAK2
Applications
WB

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Data

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rabbit
Immunogen
PN:I-492
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Mouse IL-1 Receptor Associated Kinase 2 (IRAK2) recognizes an epitope near the C-terminus of Mouse IRAK2. This polyclonal antibody was purified using affinity chromatography.
Background
The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2.1 Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-κB activation.2,3 Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, mouse IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion.4 IRAK2 is expressed in a variety of tissues.

Antigen Details

PubMed

References & Citations

1. Muzio, M. et al. (1997) Science 278:1612
2. Zhang, FX. et al. (1999) J. Biol. Chem. 274:7611
3. Yang, RB. et al. (1999) J. Immunol. 163:639
4. Hardy, MP. and O'Neill, LA. (2004) J Biol Chem. 279(26):27699-708.
General Western Blot Protocol

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.