Anti-Mouse Receptor Interacting Protein 3 (RIP3)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Mouse Receptor Interacting Protein 3 (RIP3)

Pricing & Details

Product No.R1001
Protein
RIP-3
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
R1001-20 µg
20 µg
$95.00
In stock
Max:
Min: 1
Step: 1
R1001-0.1 mg
0.1 mg
$440.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Rabbit
Immunogen
PN:R1008
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Mouse Receptor Interacting Protein 3 (RIP3) recognizes Mouse and Rat RIP3. This polyclonal antibody was purified using affinity chromatography.
Background
Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3.1-3 RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-κB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.2,3

Antigen Details

Protein
PubMed

References & Citations

1. Yu, PW. et al. (1999) Curr. Biol. 9(10):539
2. Sun, X. et al. (1999) J. Biol. Chem. 274(24):16871
3. Pazdernik, NJ. et al. (1999) Mol. Cell Bio. 19(10):6500
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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