Anti-TERE1 Antibody (34031)

Synthetic peptide corresponding to amino acids 32-45 of human TERE1. This sequence is 85

PBS, pH 7.4.

Liquid

Purified by Protein G affinity chromatography

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to TERE1

A ubiquitously expressed gene designated TERE1 (Transitional Epithelial Response Gene 1), which maps to chromosome 1p36.11-1p36.33, has a significant effect on growth regulation of bladder cancer and may play an equally significant role in growth regulation of prostate cancer. The TERE1 gene is located between the micro- satellite markers D1S2667 and D1S434, a chromosome locus that has been identified as a site of a tumor suppressor gene or genes for multiple tumor types. Induced TERE1 expression in two prostate carcinoma cell lines, LNCaP and PC-3, decreased proliferation up to 80% with a significant increase in the number of cells in G1. The TERE1 transcript is present in most normal human tissues, but is reduced or absent in the majority of muscle invasive TCC (Transitional Cell Carcinoma of the bladder) tumors.

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. {PubMed:20953171, PubMed:23374346}.