Anti-Insulin receptor (INSR) Monoclonal Antibody (Clone 18-44)

Human placental insulin receptor

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.

Liquid

Purified by Protein G affinity chromatography

This monoclonal antibody is stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Next Day 2-8°C

Clone 18-44 a monoclonal antibody is specific to human insulin receptor; low-level cross-reactivity with bovine and rabbit samples. and rabbit insulin receptor.

The insulin receptor (INSR) is a crucial receptor tyrosine kinase (RTK) that plays a central role in regulating glucose uptake in the body. When insulin binds to the extracellular domain of the INSR, it triggers a cascade of events leading to the absorption of glucose by cells.

The INSR shares significant structural and functional similarities with the IGF-1 receptor (IGF-1R), highlighting their related roles in cellular signaling. One of the earliest cellular responses to insulin stimulation is the autophosphorylation of tyrosine residues within the INSR, a critical step in initiating the downstream signaling pathways.

In humans, the gene encoding the INSR is located on chromosome 19. Dysfunctions or defects in the INSR can lead to a range of insulin resistance syndromes, impacting the body's ability to respond effectively to insulin. Similarly, defects in the IGF-1R can contribute to certain forms of growth retardation.

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically rUniProtKB:P15208, PubMed:12138094, PubMed:16314505, PubMed:16831875, PubMed:8257688, PubMed:8276809, PubMed:8452530, PubMed:9428692}.

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