Recombinant Human CD23 (Soluble)

CD23 (cluster of differentiation 23), also known as Fc epsilon RII or FcεRII, is a type 2 transmembrane C-type lectin and a member of the Ig family that is expressed on most mature B cells. CD23 is a surface marker of activated B cells as well as a low-affinity Fc receptor for IgE.¹ CD23 has pleiotropic roles in the control of lymphocyte behaviour, suggesting that CD23 may interact with another ligand in addition to IgE.² CD23 is important in the differentiation of chronic lymphocytic leukemia (CLL) from other lymphoid leukemias.³

MELQVSSGFV CNTCPEKWIN FQRKCYYFGK GTKQWVHARY ACDDMEGQLV SIHSPEEQDF LTKHASHTGS WIGLRNLDLK GEFIWVDGSH VDYSNWAPGE PTSRSQGEDC VMMRGSGRWN DAFCDRKLGA WVCDRLATCT PPASEGSAES MGPDSRPDPD GRLPTPSAPL HS

Lyophilized

The molecular weight of Recombinant Human sCD23 is Mr 19.2 kDa.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Sakai, H. et al. (1992) Nephron 60: 404
2. Jean-Yves et al. (1992) Nature 358: 505
3. Keating, M. et al. (2002) Cancer 94: 172