Recombinant Human EG-VEGF

Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF/PK-1) is a member of the prokineticin family of secreted proteins. It is expressed in various tissues including the GI tract and steroidogenic glands (1). EG-VEGF promotes angiogenesis acting via two G-protein coupled receptors, PK-R1 and PK-R2 (2). EG-VEGF results in the activation of MAPK p44/42 and phosphatidylinositol 3-kinase signaling pathways, leading to proliferation, migration, and survival of responsive endothelial cells (3).

Histidine Tag

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Ala20

Lyophilized

The predicted molecular weight of Recombinant Human EG-VEGF is Mr 10.5 kDa.

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) with BSA as a carrier protein. pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Meidan, R. et al. (2005) Endocrinology. 146(9):3950-8.
2. Ferrara, N. et al. (2002) Cold Spring Harb Symp Quant Biol.67:217-21.
3. Ferrara, N. et al. (2002) J Biol Chem. 277(10):8724-9.