Recombinant Human Eotaxin-3 (CCL-26)

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Pricing & Details

Product. No.E118
Alternate Names
SCYA26, MIP-4 Alpha, Eotaxin-3, IMAC, MIP-4a, TSC-1, CCL26
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
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E118-25 µg
25 µg
$249.00
In stock
Max:
Min: 1
Step: 1

Background

Eotaxin-3/CCL-26 belongs to a family of CC chemokines, which are potent chemoattractants for eosinophils that signal through the CCR3 receptor. 1 It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. It has been reported that eotaxin-3 is an antagonist for CCR2.2 Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Eotaxin-3 is up-regulated in the context of a T helper 2 mediated inflammatory bowel disease via the signal transducer and activator of transcription 6, thus suggesting that the intestinal epithelium actively participates in the recruitment of eosinophils at the site of inflammation.1

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human Eotaxin-3 was determined by its ability to induce chemotaxis of mouse BaF/3 cells stably expressing mCCR3. The expected ED50 for this effect is typically 0.2 - 0.8 μg/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
trgsdis ktccfqyshk plpwtwvrsy eftsnscsqr avifttkrgk kvcthprkkw vqkyisllkt pkql
N-terminal Sequence Analysis
Thr24
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human Eotaxin-3 is Mr 8.4 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Cuber, JC.et al. (2005) Int J Biochem Cell biol. 37: 2559
2. Gerber, B. et al. (2004) J Biol Chem. 279: 23357
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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