Recombinant Human GFRα-3

GDNF family receptor alpha 3, also known as GFRA3 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family of ligands, artemin. The major site of GFRalpha3 expression is in the dorsal root ganglion.

GFRalpha3 artemin neurons are immunopositive for markers expected of nociceptors and include a subset of neurons distinct from the GDNF-responsive population.¹

Fc Fusion Protein

gdplptesrl mnsclqarrk cqadptcsaa yhhldsctss istplpseep svpadcleaa qqlrnsslig cmchrrmrnq vacldiywtv hrarslgnye ldvspyedtv tskpwkmnls klnmlkpdsd lclkfamlct lndkcdrlrk aygeacsgph cqrhvclrql ltffekaaep haqglllcpc apndrgcger rrntiapnca lppvapncle lrrlcfsdpl crsrlvdfqt hchpmdilgt cateqsrclr aylgligtam tpnfvsnvnt svalsctcrg sgnlqeecem legffshnpc lteaiaakmr fhsqlfsqdw phptfavmah qnenpavrpq pwiegrmdpk scdkthtcpp cpapellggp svflfppkpk dtlmisrtpe vtcvvvdvsh edpevkfnwy vdgvevhnak tkpreeqyns tyrvvsvltv lhqdwlngke ykckvsnkal papiektisk akgqprepqv ytlppsrdel tknqvsltcl vkgfypsdia vewesngqpe nnykttppvl dsdgsfflys kltvdksrwq qgnvfscsvm healhnhytq kslslspgkh hhhhh (Human GFRα-3 Asp32-Trp382)

Gly31 & Asp32

Lyophilized

The predicted molecular weight of Recombinant Human GFRα-3 is Mr 67 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 67 kDa.

67

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Sanicola, M. et al. (2001)Eur J Neurosci 13: 2177