Recombinant Human Leptin R

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Pricing & Details

Product. No.L195
Alternate Names
Leptin Receptor, OB-R, B219, CD295
Expression Host
NS0 cells
Species
Human
Prod No.
Size
Price
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Qty
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L195-100 µg
100 µg
$379.00
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Background

Leptin receptor, also known as LEPR, and CD295 (cluster of differentiation 295) is a single-transmembrane-domain receptor of the cytokine-receptor family.1 Leptin receptor exists in multiple forms with a common extracellular domain and a variable length cytoplasmatic portion. Leptin receptor may act as a negative regulator of Leptin activity and it may maintain a pool of available bioactive Leptin by binding and delaying its clearance from circulation. Leptin receptor is considered a physiological marker of primate fetal lung maturity.2

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human Leptin R was determined by its ability to neutralize the activity of recombinant Human Leptin on leptin-dependent human OB-R transfected murine BaF3 cells. The expected ED50 is typically 0.02 - 0.12 μg/ml in the presence of 3 ng/ml rhLeptin.
Fusion Protein Tag
Fc Fusion Protein
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
t afnlsypitp wrfklscmpp nstydyfllp aglskntsns nghyetavep kfnssgthfs nlskttfhcc frseqdrncs lcadniegkt fvstvnslvf qqidanwniq cwlkgdlklf icyveslfkn lfrnynykvh llyvlpevle dsplvpqkgs fqmvhcncsv hecceclvpv ptaklndtll mclkitsggv ifqsplmsvq pinmvkpdpp lglhmeitdd gnlkiswssp plvpfplqyq vkysensttv ireadkivsa tsllvdsilp gssyevqvrg krldgpgiws dwstprvftt qdviyfppki ltsvgsnvsf hciykkenki vpskeivwwm nlaekipqsq ydvvsdhvsk vtffnlnetk prgkftydav yccnehechh ryaelyvidv niniscetdg yltkmtcrws tstiqslaes tlqlryhrss lycsdipsih pisepkdcyl qsdgfyecif qpifllsgyt mwirinhslg sldspptcvl pdsvvkplpp ssvkaeitin igllkiswek pvfpennlqf qiryglsgke vqwkmyevyd aksksvslpv pdlcavyavq vrckrldglg ywsnwsnpay tvvmdikvpm rgpefwriin gdtmkkeknv tllwkplmkn dslcsvqryv inhhtscngt wsedvgnhtk ftflwteqah tvtvlainsi gasvanfnlt fswpmskvni vqslsaypln sscvivswil spsdyklmyf iiewknlned geikwlriss svkkyyihdh fipiekyqfs lypifmegvg kpkiinsftq ddiekhqsdi iegrpkscdk thtcppcpap ellggpsvfl fppkpkdtlm isrtpevtcv vvdvshedpe vkfnwyvdgv evhnaktkpr eeqynstyrv vsvltvlhqd wlngkeykck vsnkalpapi ektiskakgq prepqvytlp psrdeltknq vsltclvkgf ypsdiavewe sngqpennyk ttppvldsdg sfflyskltv dksrwqqgnv fscsvmheal hnhytqksls lspgkhhhhh h
N-terminal Sequence Analysis
Thr20
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human Leptin R is Mr 121 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 155-175 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Guy-Grand, B. et al.(1998) Nature 392: 398
2. Castracane, VD. et al.(2004) Reproduction 127: 87
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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