Transmembrane activator & calcium modulator and cyclophilin ligand (CAML) interactor (TACI) is lymphocyte specific member1,2 of the tumor necrosis factor-receptor superfamily3 and is expressed in B-lymphocytes and may act to regulate humoral immunity.4 TACI also serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a proliferation-inducing ligand (APRIL).5
>98% by SDS-PAGE and HPLC
<0.1 ng per 1 µg as determined by the LAL method
The biological activity of Human Transmembrane Activator and CAML Interactor is determined by its ability to block human BAFF induced T2B cell survival assay using a concentration range of 1.0-3.0 ug/ml.
Amino Acid Sequence
MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human TACI is Mr 17.9 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 17.8 kDa.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Schwaller, J. et al. (2007) Blood 109: 331
2. Slazer, U. et al. (2005) Nat Genet. 37: 820
3. Bonilla, FA. et al. (2006) Curr Allergy Asthma Rep. 6: 357
4. Bram, RJ. et al. (2000) Mamm Genome. 11: 628
5. Kobata, T. et al. (2007) Blood 109: 2961
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.