Recombinant Mouse IL-13 Rα2

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Pricing & Details

Product. No.I-567
Alternate Names
Interleukin-13 Receptor Alpha 2, IL13RA2, CD213A2, IL-13R, IL13BP
Expression Host
NS0 cells
Species
Mouse
Prod No.
Size
Price
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Qty
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I-567-100 µg
100 µg
$359.00
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Max:
Min: 1
Step: 1

Background

Interleukin 13 receptor alpha 2, also known as IL13RA2 and CD213A2, binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 serves as a dominant negative inhibitor or a decoy receptor for IL-13.1 IL-13Ralpha2 is a promising target for ovarian cancer therapy, and the soluble form of IL-13R may be a possible surrogate marker for disease monitoring.2 IL13RA2 signaling during prolonged inflammation is also an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis.3

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
leikvnppq dfeildpgll gylylqwkpp vviekfkgct leyelkyrnv dsdswktiit rnliykdgfd lnkgiegkir thlsehctng sevqspwiea sygisdegsl etkiqdmkci yynwqylvcs wkpgktvysd tnytmffwye gldhalqcad ylqhdeknvg cklsnldssd ykdfficvng ssklepirss ytvfqlqniv kplppeflhi svensidirm kwstpggpip prcytyeivi reddiswesa tdkndmklkr ranesedlcf fvrckvniyc addgiwsews eeecwegytg pdskiegrdi dpkscdktht cppcpapell ggpsvflfpp kpkdtlmisr tpevtcvvvd vshedpevkf nwyvdgvevh naktkpreeq ynstyrvvsv ltvlhqdwln gkeykckvsn kalpapiekt iskakgqpre pqvytlppsr deltknqvsl tclvkgfyps diavewesng qpennykttp pvldsdgsff lyskltvdks rwqqgnvfsc svmhealhnh ytqkslslsp gk
N-terminal Sequence Analysis
Leu22
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-13 Rα2 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 85-90 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Low, WC. et al. (2003) Neuro Oncol. 5: 179
2. Puri, RK. et al. (2006) Cancer 107: 1407
3. Kitani, A. et al. (2006) Nat Med. 12: 99
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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