Anti-Human IL-13 Rα2 (Clone 83834)

NS0-Derived Recombinant Human Interleukin-13 Receptor α2 Extracellular Domain (Accession # Q14627)

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

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Mouse Anti-Human Interleukin-13 Receptor Alpha 2 (IL-13 Rα2) (Clone 83834) recognizes an epitope on Human IL-13 Rα2. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody shows no cross-reactivity with rhIL-5 Rα, rhIL-5 Rβ, rhIL-13 Rα1 and rmIL-13 Rα2 and approximately 5% cross-reactivity with rhIL-4 R and rhIL-9 R.

Interleukin 13 receptor alpha 2, also known as IL13RA2 and CD213A2, binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 serves as a dominant negative inhibitor or a decoy receptor for IL-13.¹ IL-13Ralpha2 is a promising target for ovarian cancer therapy, and the soluble form of IL-13R may be a possible surrogate marker for disease monitoring.² IL13RA2 signaling during prolonged inflammation is also an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis.³

1. Low, WC. et al. (2003) Neuro Oncol. 5: 179
2. Puri, RK. et al. (2006) Cancer 107: 1407
3. Kitani, A. et al. (2006) Nat Med. 12: 99