Recombinant Mouse P-Selectin

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Pricing & Details

Product. No.P260
Alternate Names
Plasma Selectin, SELP, CD62, CD62P, FLJ45155, Granule Membrane Protein (GMP140), GRMP, Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM), PSEL
Expression Host
NS0 cells
Prod No.
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P260-50 µg
50 µg
In stock
Min: 1
Step: 1
P260-200 µg
200 µg
In stock
Min: 1
Step: 1
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Plasma Selectin (P-selectin) is a cell adhesion molecule (CAM) found in granules in endothelial cells (cells lining blood vessels) and activated platelets. P-Selectin is expressed on activated endothelium and platelets where it can bind monocytes, neutrophils, stimulated T cells, and platelets.1 P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface. Thrombin is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca2+-independent pathway involved in release of P-selectin.2 P-selectin-mediated adhesion is an important factor in the development of early atherosclerotic lesions.1

Protein Details

>90% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
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N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse P-Selectin is Mr 99.1 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 190-200 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from 1X PBS with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Wagner, DD. et al. (1997) J Clin Invest. 99: 1037
2. Cleator, JH. et al. (2006) Blood 107: 2736
Elisa Sandwich Protocol
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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