Recombinant Mouse Persephin

Recombinant Mouse Persephin

Product No.: P233

[product_table name="All Top" skus="P233"]

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Target
Persephin
Product Type
Recombinant Protein
Alternate Names
PSPN

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Expression Host
E. coli Cells
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Purity
>98% by SDS Page and HPLC
State of Matter
Lyophilized
Storage and Handling
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
Amino Acid Sequence
The DNA sequence encoding the TGF-β-like domain of mouse Persephin (Ala 61 - Gly 156) was inserted into a suitable expression vector and was expressed in E. coli (Tomac, A.C. et al., 2002, Proc. Natl. Acad. Sci. USA 99:9521 - 6526).
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Background
Persephin (PSP) is a secreted protein belonging to the glial cell line-derived neurotrophic factor (GDNF) family of the TGF-b superfamily. Just like factor GDNF and neurturin (NTN), PSP promotes the survival of ventral midbrain dopaminergic neurons and prevents their degeneration. Persephin also supports the survival of motor neurons.1 Persephin is expressed at very low levels in most tissues. It is synthesized throughout the nervous system and has both astroglial and neuronal origin.2

Antigen Details

PubMed
NCBI Gene Bank ID

References & Citations

1. Johnson, EM. et al. (1998) Neuron 20: 2452. Krieglstein K. et al. (1998) J Neurosci Res. 53: 494
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.