Anti-SAP30L Antibody (28113)

Synthetic peptide corresponding to amino acids 165-183 (VKSNKSRLDQKSEGGKQLE) of human SAP30L conjugated to KLH at the N- terminus.

PBS, pH 7.4.

Liquid

Purified by immunoaffinity chromatography

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to SAP30L

A novel TGF-beta up-regulated mRNA species, the Sin3-associated protein 30- like, SAP30L has been identified. The predicted nuclear localization signal of SAP30L is sufficient for nuclear transport of the protein although mutating it does not completely remove SAP30L from the nuclei. By reason of its nuclear localization and close homology to SAP30, it is thought that SAP30L might have a role in recruiting the Sin3-histone deacetylase complex to specific co- repressor complexes in response to TGF- beta, leading to the silencing of proliferation-driving genes in the differentiating intestinal epithelial cells.

[Isoform 1]: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). {PubMed:16820529, PubMed:18070604, PubMed:19015240, PubMed:26609676}.; [Isoform 2]: Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. {PubMed:18070604}.; [Isoform 3]: Functions as transcription repressor; its activity is marginally lower than that of isoform 1. {PubMed:18070604}.

Lindfors,K. et al. BMC Genomics 4 (1), 53 (2003).