Anti-NKX3.1 (NT) Antibody (34013)

Synthetic peptide corresponding to aa residues 21-37 (TPSKPLTSFLIQDILRD) of human NKX3.1 conjugated to KLH at the C- terminus.

PBS, pH 7.4.

Liquid

Purified by peptide immuno-affinity chromatography

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to NKX3.1 Antibody (NT)

NKX3.1 is a homeobox gene which exhibits prostate- and testis-specific expression. Loss of NKX3.1 expression has been implicated in prostate development and tumorigenesis. NKX3.1 expression is dramatically down-regulated in testicular cancer of germ cell origin. Results suggest that NKX3.1 is essential for normal testis function and that its loss of expression is highly associated with the invasive phenotype of testicular germ cell tumors.

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {PubMed:19462257}.

Lind GE. et al. (2005) Mol Cancer. 4:8.
Gelmann E.P. et al. (2003) Prostate 55:111-117.