Anti-Avian Influenza Hemagglutinin (NT)

Anti-Avian Influenza Hemagglutinin (NT)

Product No.: H1464

[product_table name="All Top" skus="H1464"]

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Target
Hemagglutinin
Product Type
Polyclonal Antibody
Applications
ELISA Indirect

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Product Size
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Antibody Details

Product Details

Reactive Species
Avian Influenza
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Avian Influenza Hemagglutinin recognizes Avian Influenza Hemagglutinin. This polyclonal antibody was purified using affinity chromatography.
Background
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA.1 Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found.2 These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong.3 There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low.4 HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.

Antigen Details

Research Area
Seasonal and Respiratory Infections

References & Citations

1. Thompson, W. W. et al. (2003) JAMA 289:179 2. Alexander, D. J. (2000) Vet. Microbiol. 74:3 3. Shortridge, K. F. et al. (1998) Virol. 252:331 4. Buxton Bridges, C. et al. (2000) J. Inf. Dis. 181:344
Indirect Elisa Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.