Anti-Avian Influenza Hemagglutinin (Intermediate Domain)
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Antibody DetailsProduct DetailsReactive Species Avian Influenza Host Species Rabbit Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830313 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Avian Influenza Hemagglutinin recognizes Avian Influenza Hemagglutinin. This polyclonal antibody was purified using affinity chromatography. Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA.1 Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found.2 These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong.3 There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low.4 HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability. PubMed Research Area Infectious Disease . Seasonal and Respiratory Infections . IVD Raw Material References & Citations1. Thompson, W. W. et al. (2003) JAMA 289:179
2. Alexander, D. J. (2000) Vet. Microbiol. 74:3
3. Shortridge, K. F. et al. (1998) Virol. 252:331
4. Buxton Bridges, C. et al. (2000) J. Inf. Dis. 181:344 Technical ProtocolsCertificate of Analysis |
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