Anti-Avian Influenza Nonstructural Protein 1(H5N1 NS1)

Home/Primary Monoclonal Antibodies/Infectious Diseases/Anti-Avian Influenza Nonstructural Protein 1(H5N1 NS1)

Pricing & Details

Product No.H1461
Protein
H5N1 NS1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Nonstructural Protein 1
Applications
ELISA Indirect
Prod No.
Size
Price
Avail.
Qty
Add to cart
H1461-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
H1461-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Avian
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-H5N1 NS1 recognizes H5N1 NS1. This polyclonal antibody was purified using affinity chromatography.
Background
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes, including the so-called “avian flu” or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2’-5’ OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the anti-viral protein kinase PKR.

Antigen Details

Protein
PubMed

References & Citations

1. Thompson, W. W. et al. (2003) JAMA 289:179 2. Alexander, D. J. (2000) Vet. Microbiol. 74:3 3. Krug, R. M. et al. (2003) Virology 309:181 4. Min, J. Y. et al. (2006) Proc. Natl. Acad. Sci. USA 103:7100
Indirect Elisa Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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