Anti-Bovine PKC Agarose

Anti-Bovine PKC Agarose

Product No.: P110

[product_table name="All Top" skus="P110"]

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Clone
MC5
Target
Protein Kinase C
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
IgG2a

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Antibody Details

Product Details

Reactive Species
Bovine
Host Species
Mouse
Formulation
Anti-Protein Kinase C-Agarose is supplied in 0.01 M phosphate buffered saline (PBS) pH 7.2, 0.09% sodium azide as a preservative.
Storage and Handling
Stable when stored at 2 - 8°C.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Anti-Protein Kinase C (PKC) recognizes the intact (Mr 79-80 kDa) calcium-activated, phospholipid-dependent Protein Kinase C in bovine brain. The antibody strongly cross-reacts with PKC in human, mouse and rat cells.1 Anti-PKC (clone MC5) binds to an epitope at the hinge region of the enzyme, the site of phorbol-ester-induced proteolysis which is thought to down-regulate PKC activity in intact cells.1,2 Monoclonal MC5 reacts with PKC-α/ß12 isoforms.
Background
Anti-Protein Kinase C (PKC) has been covalently conjugated to 4% cross-linked agarose using conjugation chemistries to reduce non-specific binding and optimize binding of Protein Kinase C. Anti-Protein Kinase C-Agarose may be used to isolate Protein Kinase C.

Bead Size
75-300 µm (50-200 mesh)
Research Area
Apoptosis
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Cell Biology
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Immunology

References & Citations

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.