Anti-Bovine PKC-Biotin

Pricing & Details

Product No.P108
Clone
MC5
Protein
Protein Kinase C
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
Mouse
IgG2a
Applications
IHC FF
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
P108-0.25 mg
0.25 mg
$277.00
In stock
Max:
Min: 1
Step: 1

Antibody Details

Product Details

Reactivity Species
Bovine
Host Species
Mouse
Product Concentration
0.5 mg/ml
Formulation
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Protein Kinase C (PKC) recognizes the intact (Mr 79-80 kDa) calcium-activated, phospholipid-dependent Protein Kinase C in bovine brain. The antibody strongly cross-reacts with PKC in human, mouse and rat cells.1 Anti-PKC (clone MC5) binds to an epitope at the hinge region of the enzyme, the site of phorbol-ester-induced proteolysis which is thought to down-regulate PKC activity in intact cells.1,2 Monoclonal MC5 reacts with PKC-α/ß12 isoforms.
Background
Anti-PKC-Biotin (clone MC5) may be used to block both proteolysis and down-regulation of PKC activity. The antibody reacts with the intact molecule and may be used to localize PKC activity and to study the role of proteolysis in the activation of the Protein Kinase C pathway.

Antigen Details

Research Area
Apoptosis
.
Cell Biology
.
Immunology

References & Citations

1. Young, S. et al. (1988) Eur. J. Biochem. 172:247
2. Young, S. et al. (1987) Biochem. J. 244:775
IHC
General Western Blot Protocol

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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