Anti-Bovine PKC-Biotin

Product No.: P108


Clone MC5 Target Protein Kinase C Formats AvailableView All Product Type Monoclonal Antibody Isotype IgG2a Applications IHC FF , WB


Select Product Size 0.25 mg — $304.00	Qty Max: Min: 1 Step: 1 $304.00 ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities


Antibody Details Product Details Reactive Species Bovine Host Species Mouse Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2831508 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Anti-Protein Kinase C (PKC) recognizes the intact (Mr 79-80 kDa) calcium-activated, phospholipid-dependent Protein Kinase C in bovine brain. The antibody strongly cross-reacts with PKC in human, mouse and rat cells.¹ Anti-PKC (clone MC5) binds to an epitope at the hinge region of the enzyme, the site of phorbol-ester-induced proteolysis which is thought to down-regulate PKC activity in intact cells.^1,2 Monoclonal MC5 reacts with PKC-α/ß₁/ß₂ isoforms. Background Anti-PKC-Biotin (clone MC5) may be used to block both proteolysis and down-regulation of PKC activity. The antibody reacts with the intact molecule and may be used to localize PKC activity and to study the role of proteolysis in the activation of the Protein Kinase C pathway. Research Area Apoptosis . Cell Biology . Immunology References & Citations 1. Young, S. et al. (1988) Eur. J. Biochem. 172:247 2. Young, S. et al. (1987) Biochem. J. 244:775 View product citations for antibody P108 on CiteAb Technical Protocols IHC FF Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Bovine

Host Species

Mouse

Product Concentration

0.5 mg/ml

Formulation

This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

Storage and Handling

This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

RRIDAB_2831508

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Anti-Protein Kinase C (PKC) recognizes the intact (Mr 79-80 kDa) calcium-activated, phospholipid-dependent Protein Kinase C in bovine brain. The antibody strongly cross-reacts with PKC in human, mouse and rat cells.¹ Anti-PKC (clone MC5) binds to an epitope at the hinge region of the enzyme, the site of phorbol-ester-induced proteolysis which is thought to down-regulate PKC activity in intact cells.^1,2 Monoclonal MC5 reacts with PKC-α/ß₁/ß₂ isoforms.

Background

Anti-PKC-Biotin (clone MC5) may be used to block both proteolysis and down-regulation of PKC activity. The antibody reacts with the intact molecule and may be used to localize PKC activity and to study the role of proteolysis in the activation of the Protein Kinase C pathway.

Research Area

Apoptosis

Cell Biology

Immunology

References & Citations

1. Young, S. et al. (1988) Eur. J. Biochem. 172:247
2. Young, S. et al. (1987) Biochem. J. 244:775

View product citations for antibody P108 on CiteAb

IHC FF

Certificate of Analysis

Request COA

Formats Available

Prod No.	Description
P321	Anti-Bovine PKC – DyLight® 488
P322	Anti-Bovine PKC – DyLight® 550
P323	Anti-Bovine PKC – DyLight® 594
P325	Anti-Bovine PKC – DyLight® 650
P326	Anti-Bovine PKC – DyLight® 680
P327	Anti-Bovine PKC – DyLight® 755
P107	Anti-Bovine PKC Protein Kinase C Purified
P108	Anti-Bovine PKC-Biotin
P109	Anti-Bovine PKC – FITC
P110	Anti-Bovine PKC Agarose

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Anti-Bovine PKC-Biotin