Anti-Ceramide Kinase Antibody (13805)

Synthetic peptide conjugated to KLH.

PBS containing 0.1% sodium azide

Liquid

Purified by peptide immuno-affinity chromatography

This antibody is stable at 4°C (short- term) and -70°C (long-term).

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to Ceramide Kinase

Ceramide kinase (CERK), which phosphorylates ceramide to produce ceramide 1-phosphate (C1P), was first described as a Ca+2-stimulated lipid kinase that copurified with brain synaptic vesicles. CERK activity has been reported in HL60 cells, mast cells, and neutrophils. CERK is involved in phagolysosome formation in plymorphonuclear leukocytes and also in liposome fusion. C1P has been reported to have mitogenic effects. More recently, C1P was found to induce arachidonic acid release and prostanoid synthesis.

Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031). {PubMed:11956206, PubMed:16269826, PubMed:19168031}.