Anti-CNS Myelin/Oligodendrocytes

Anti-CNS Myelin/Oligodendrocytes

Product No.: D103

[product_table name="All Top" skus="D103"]

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Clone
CE1
Target
Oligodendrocytes
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Clone AERA8-154, CNS Myelin
Isotype
IgM
Applications
IHC FFPE

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Mouse Anti-CNS Myelin/Oligodendrocytes (Clone AERA8-154 (CE1)) recognizes Myelin and Oligodendrocytes in the CNS. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Myelin is an electrically-insulating dielectric phospholipid layer that surrounds the axons of many neurons. It is an outgrowth glial cell: Schwann cells supply the myelin for peripheral neurons, whereas oligodendrocytes supply it to those of the central nervous system. Myelin is considered a defining characteristic of the (gnathostome) vertebrates, but it has also arisen by parallel evolution in some invertebrates. Myelin made by different cell types varies in chemical composition and configuration, but performs the same insulating function. Myelinated axons are white in appearance. Myelin is composed of about 80% lipid fat and about 20% protein. Some of the proteins that make up myelin are Myelin basic protein (MBP), Myelin oligodendrocyte glycoprotein (MOG), and Proteolipid protein (PLP).
Antigen Distribution
The MOSP antigen is present on oligodendrocytes and CNS myelin but not on Schwann cells or peripheral nervous system (PNS) myelin. No specific staining is observed in sections from PNS, retina, liver, skin, or kidney.
Research Area
Cell Biology
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Neuroinflammation
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Neuroscience
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Neuroscience Cell Markers

References & Citations

1. Dyer, C. A. et al. (1991) J. of Neuroscience 28:607
IHC FFPE

Certificate of Analysis

Formats Available

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Prod No.
Description
D103
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.