Anti-Gonadotropin Releasing Hormone (GnRH) [Clone LHRH13-327.8]
Anti-Gonadotropin Releasing Hormone (GnRH) [Clone LHRH13-327.8]
Product No.: 19301
Clone LHRH13-327.8 Target Gonadotropin Releasing Hormone Formats AvailableView All Product Type Primary Monoclonal Antibody Alternate Names Progonadoliberin I [Cleaved into: Gonadoliberin-1 Isotype Mouse IgG1 Applications ELISA , IHC , RIA |
Data
RIAAntibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Purified human GnRh Product Concentration Lot Specific Formulation This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added. State of Matter Liquid Product Preparation Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. Storage and Handling This antibody is stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco These antibodies have been qualified for use in ELISA, immunohistochemistry, and RIA to detect human GnRH.
Endusers should determine optimal concentrations for their applications.RIA Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity This antibody recognize human GnRH. Background Target Background: Gonadotropin Releasing Hormone (GnRH / LHRH)Gonadotropin Releasing Hormone (GnRH)—also known as Luteinizing Hormone-Releasing Hormone (LHRH), GNRH1, LHRF, or Progonadoliberin I—is a highly conserved decapeptide (pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) essential for regulating the mammalian reproductive axis. Because GnRH is secreted in low-concentration, pulsatile bursts into the hypophyseal portal bloodstream, accurate and highly sensitive detection is critical for both basic research and clinical assay development. Overview for Assay Developers & DiagnosticsFor immunoassay developers, GnRH represents a challenging yet vital biomarker. Its small decapeptide molecular weight requires high-affinity, rigorously validated primary monoclonal antibodies to ensure robust sensitivity and specificity across sandwich ELISAs, competitive ELISAs, Radioimmunoassays (RIA), and rapid lateral flow diagnostic platforms. This purified mouse monoclonal anti-GnRH antibody (SKU: 19301) offers high target specificity and binding affinity, making it an excellent candidate for assay developers building high-sensitivity capture/detection matched pairs, evaluating peptide cross-reactivity, or standardizing commercial diagnostic kits. Biological Significance & Key Research AreasSynthesized primarily in the preoptic area of the hypothalamus, GnRH serves as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Upon release, it binds to the GnRH receptor (GnRHR) on anterior pituitary gonadotropes, triggering the synthesis and secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). Primary research areas and target applications include:
Function Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. NCBI Gene Bank ID UniProt.org Research Area Hormones . Hormones/Proteins References & CitationsTechnical Protocols  RIA Certificate of Analysis |
Related Products
Prod No. | Description |
|---|---|
R254 | |
19302 | |
19303 | |
19304 | |
193101 |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
