Anti-Human Anthrax Toxin Receptor (CT) (ATR)

Anti-Human Anthrax Toxin Receptor (CT) (ATR)

Product No.: A287

[product_table name="All Top" skus="A287"]

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Target
Anthrax Toxin Receptor
Product Type
Polyclonal Antibody
Alternate Names
TEM8
Applications
IHC FFPE
,
WB

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Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Anthrax Toxin Receptor (ATR) recognizes an epitope near the C-terminus of Human, Mouse and Rat ATR. This polyclonal antibody was purified using affinity chromatography.
Background
The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8).1 This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin.2 Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF).3 This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.4

Antigen Details

References & Citations

1. Carson-Walter, E. B. et al. (2001) Can. Res. 61:6649 2. Bradley, K. A. et al. (2001) Nature 414:225 3. Molloy, S. et al. (1992) J. Biol. Chem. 267:16396 4. Duesbery, N. et al. (1998) Science 280:734
IHC FFPE
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.