Anti-Human APOBEC3G (NT)

Pricing & Details

Product No.A293
Protein
APOBEC3G
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A293-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
A293-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A320
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human APOBEC3G recognizes an epitope near the N-terminus of Human APOBEC3G. This polyclonal antibody was purified using affinity chromatography.
Background
The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates.1 Similar to TRIM5α which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection2,3 as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome.4 This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.

Antigen Details

Protein
PubMed

References & Citations

1. Jarmuz, A. et al. (2002) Genomics 79:285 2. Stremlau, M. et al. (2004) Nature 427:848 3. Bieniasz, P. D. (2004) Nat. Immunol. 5:1109 4. Sheehy, A. M. et al. (2002) Nature 418:646
IHC
General Western Blot Protocol
Prod No.
Description
A320
A293
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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