Anti-Human Apoptosis signal-regulating kinase (NT) (ASK1)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Apoptosis signal-regulating kinase (NT) (ASK1)

Pricing & Details

Product No.A251
Protein
ASK1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Apoptosis Signal-Regulating Kinase, MAPKKK, MEK kinase 5
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A251-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
A251-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A265
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Apoptosis signal-regulating kinase (ASK1) recognizes an epitope near the N-terminus of human and mouse ASK1. This polyclonal antibody was purified using affinity chromatography.
Background
Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5.1-3 ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-Α-induced apoptosis. ASK1 is expressed in variety of tissues and cell lines.

Antigen Details

Protein
PubMed

References & Citations

1. Ichijo, H. et al. (1997) Science 275:90-4.
2. Wang, XS. et al. (1996) J. Biol. Chem. 271:31607-11.
3. Tobiume, K. et al. (1997) M Biochem. Biophys. Res. Commun. 239:905-10.
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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