Anti-Human Apoptosis signal-regulating kinase (NT) (ASK1)
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:A265 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2828077 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Human Apoptosis signal-regulating kinase (ASK1) recognizes an epitope near the N-terminus of human and mouse ASK1. This polyclonal antibody was purified using affinity chromatography. Background Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5.1-3 ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-Α-induced apoptosis. ASK1 is expressed in variety of tissues and cell lines. Antigen DetailsPubMed References & Citations1. Ichijo, H. et al. (1997) Science 275:90-4. 2. Wang, XS. et al. (1996) J. Biol. Chem. 271:31607-11. 3. Tobiume, K. et al. (1997) M Biochem. Biophys. Res. Commun. 239:905-10. Technical Protocols |
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