Anti-Human B Cell Receptor-Associated Protein 31 (CT) (BAP31)

PN:B499

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human B Cell Receptor-Associated Protein 31 (BAP31) recognizes an epitope near the C-terminus of Human, Mouse and Rat BAP31. This polyclonal antibody was purified using affinity chromatography.

Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family.^1,2 These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18.^3,4 It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death.

1. Kim, KM. et al. (1994) EMBO J. 13:3793
2. Paquet, ME. et al. (2004) J. Immunol. 172:7548
3. Zen, K. et al. (2004) J. Biol. Chem. 279:44924
4. Nguyen, M. et al. (2000) Mol. Cell. Biol. 20:6731