Anti-Human B Cell Receptor-Associated Protein 31 (CT) (BAP31)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human B Cell Receptor-Associated Protein 31 (CT) (BAP31)

Pricing & Details

Product No.B479
Protein
B Cell Receptor-Associated Protein 31
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
BCR Associated Protein 31
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
B479-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
B479-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:B499
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human B Cell Receptor-Associated Protein 31 (BAP31) recognizes an epitope near the C-terminus of Human, Mouse and Rat BAP31. This polyclonal antibody was purified using affinity chromatography.
Background
Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family.1,2 These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18.3,4 It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death.

Antigen Details

References & Citations

1. Kim, KM. et al. (1994) EMBO J. 13:3793
2. Paquet, ME. et al. (2004) J. Immunol. 172:7548
3. Zen, K. et al. (2004) J. Biol. Chem. 279:44924
4. Nguyen, M. et al. (2000) Mol. Cell. Biol. 20:6731
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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