Anti-Human B Cell Receptor-Associated Protein 31 (Intermediate D

PN:B500

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human B Cell Receptor-Associated Protein 31 (BAP31) recognizes an epitope in the intermediate domain of Human, Mouse and Rat BAP31. This polyclonal antibody was purified using affinity chromatography.

Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family.^1,2 These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18.^3,4 Bap31 may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopically, is also a potent inducer cell death.

1. Little, E. et al. (1994) Crit. Rev. Eukaryot. Gene Expr. 4:1
2. Kim, KM. et al. (1994) EMBO J. 13:3793
3. Paquet, ME. et al. (2004) J. Immunol. 172:7548
4. Zen, K. et al. (2004) J. Biol. Chem. 279:44924