Pricing & Details

Product No.B440
Protein
Bad
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Bcl-2-like 8
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
B440-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
B440-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:B465
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Bad recognizes an epitope near the C-terminus of human, mouse and rat Bad. This polyclonal antibody was purified using affinity chromatography.
Background
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death.1,2 Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax.3 Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival,4 whereas JNK-induced phosphorylation promotes the apoptotic role of Bad.5

Antigen Details

Protein
PubMed

References & Citations

1. Cory, S. et al. (2003) Oncogene 22:8590-607.
2. Heiser, D. et al. (2004) Exp. Geron. 39:1125-35.
3. Ottilie, S. et al. (1997) J. Biol. Chem. 272:30866-72.
4. Zhou, XM. et al. (2000) J. Biol. Chem. 275:25046-51.
IHC
General Western Blot Protocol
Prod No.
Description
B465
B440
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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