Anti-Human BAG-1 (NT)

Pricing & Details

Product No.B442
Protein
BAG-1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Bcl-2-binding athanogene-1, receptor-associated protein 46, RAP46
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
B442-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
B442-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:B467
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human BAG-1 recognizes an epitope near the N-terminus of human and mouse BAG-1. This polyclonal antibody was purified using affinity chromatography.
Background
Bcl-2-associated athanogene 1 (BAG-1) was first identified as an anti-apoptotic bcl-2-binding protein. Later it was found to bind the molecular chaperones Hsp70 and Hsc70 through its carboxy-terminal sequence (termed the Bag domain), resulting in the inhibition of the refolding activity of these chaperones. It is thought that by binding and inhibiting these molecular chaperones, BAG-1is able to modulate the expression level of proteins requiring chaperones to fold correctly. One such group of proteins that are affected is glucocorticoid receptors. Other reports have suggested that the level of BAG-1 expression correlates with the aggressiveness of various cancers. Multiple isoforms of BAG-1 are known to exist.

Antigen Details

Protein
PubMed

References & Citations

1. Takayama, S. et al. (1995) Cell 80:279-84.
2. Nollen, EAA. et al. (2000) Mol. Cell. Biol. 20:1083-8.
3. Cato, ACB. and Mink, S. (2001) J Steroid Biochem Mol Biol. 78(5):379-88.
4. Kajewska, M. et al. (2006) Prostate 66:801-10.
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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