Anti-Human Bcl-B

Product No.: B447

[product_table name="All Top" skus="B447"]

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Target
Bcl-B
Product Type
Polyclonal Antibody
Alternate Names
Boo, Diva, Nrh
Applications
IHC FFPE
,
WB

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Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:B473
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Bcl-B recognizes Human Bcl-B. This polyclonal antibody was purified using affinity chromatography.
Background
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predominantly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1. Despite its predicted molecular weight, Bcl-B is often at higher molecular weights, presumably due to post-translational modifications.

Antigen Details

PubMed

References & Citations

1. Cory, S. et al. (2003) Oncogene 22:8590-607
2. Heiser, D. et al. (2004) Exp. Geron. 39:1125-35.
3. Ke, N. et al. (2001) J. Biol. Chem. 276:12481-4.
4. Song, Q. et al. (1999) EMBO J. 18:167-78.
IHC FFPE
General Western Blot Protocol
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Prod No.
Description
B447
B473
Products are for research use only. Not for use in diagnostic or therapeutic procedures.